Dr. Sabine Bartel, graduate of the Research School “Lung Biology and Disease”, was honored by the German Lung Foundation for the best experimental dissertation in 2015. The award for her thesis “mircoRNA-based identification of pulmonary signaling pathways in experimental asthma – The role of the cAMP element binding protein 1 (Creb1)” was presented to her by Prof. Dr. Gerhard Sybrecht, chairman of the German Lung Foundation, during the opening ceremony of the 57th congress of the German Respiratory Society (DGP) in Leipzig.
Sabine Bartel investigated new signaling pathways relevant for asthma development, in order to identify new therapeutic approaches or preventative strategies. In mice models for experimental asthma, primary air-liquid interface cultures of primary human bronchial epithelial cells and nasal brushings from children with asthma, a new molecular axis (miRNA-Creb/Crtc-Sec 14l3) was found to be dysregulated in both mice and in children. The observed secretion of miRNAs in exosomes may be a potential mechanism that propagates the reaction to asthmatic stimuli to other cells and tissues.
Sabine Bartel is currently employed as a postdoctoral fellow at the Research Center in Borstel - Leibniz Center for Medicine and Biosciences.
The German Lung Foundation is a non-profit and registered association that is dedicated to improve the situation of patients with lung diseases. The German Lung Foundation (Deutsche Lungenstiftung e.V.) awards prizes for the best clinical and best experimental dissertation in the field of pneumology. The doctoral prize is donated by Boehringer Ingelheim Pharma GmbH.
The German Respiratory Society is an organization for respiratory disorders and is dedicated to the promotion of science, research, education, training, prevention, patient care, and rehabilitation in the field of respiratory medicine, including intensive care medicine.
Picture: Dr. Sabine Bartel and Prof. Gerhard Sybrecht. Source: Mike Auerbach/ Deutsche Lungenstiftung e.V.